New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
Identifieur interne : 000593 ( Main/Exploration ); précédent : 000592; suivant : 000594New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
Auteurs : Haitang Yang [Suisse] ; Shun-Qing Liang [Suisse, États-Unis] ; Ralph A. Schmid [Suisse] ; Ren-Wang Peng [Suisse]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
In non-small cell lung cancer (NSCLC), the most frequent oncogenic mutation in western countries is
Url:
DOI: 10.3389/fonc.2019.00953
PubMed: 31612108
PubMed Central: 6773824
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New Horizons in <italic>KRAS</italic>-Mutant Lung Cancer: Dawn After Darkness</title><author><name sortKey="Yang, Haitang" sort="Yang, Haitang" uniqKey="Yang H" first="Haitang" last="Yang">Haitang Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Shun Qing" sort="Liang, Shun Qing" uniqKey="Liang S" first="Shun-Qing" last="Liang">Shun-Qing Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>University of Massachusetts Medical School</institution>,<addr-line>Worcester, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmid, Ralph A" sort="Schmid, Ralph A" uniqKey="Schmid R" first="Ralph A." last="Schmid">Ralph A. Schmid</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Ren Wang" sort="Peng, Ren Wang" uniqKey="Peng R" first="Ren-Wang" last="Peng">Ren-Wang Peng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31612108</idno><idno type="pmc">6773824</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773824</idno><idno type="RBID">PMC:6773824</idno><idno type="doi">10.3389/fonc.2019.00953</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000982</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000982</idno><idno type="wicri:Area/Pmc/Curation">000982</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000982</idno><idno type="wicri:Area/Pmc/Checkpoint">000544</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000544</idno><idno type="wicri:Area/Ncbi/Merge">000B02</idno><idno type="wicri:Area/Ncbi/Curation">000B02</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B02</idno><idno type="wicri:Area/Main/Merge">000593</idno><idno type="wicri:Area/Main/Curation">000593</idno><idno type="wicri:Area/Main/Exploration">000593</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New Horizons in <italic>KRAS</italic>-Mutant Lung Cancer: Dawn After Darkness</title><author><name sortKey="Yang, Haitang" sort="Yang, Haitang" uniqKey="Yang H" first="Haitang" last="Yang">Haitang Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Shun Qing" sort="Liang, Shun Qing" uniqKey="Liang S" first="Shun-Qing" last="Liang">Shun-Qing Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>University of Massachusetts Medical School</institution>,<addr-line>Worcester, MA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmid, Ralph A" sort="Schmid, Ralph A" uniqKey="Schmid R" first="Ralph A." last="Schmid">Ralph A. Schmid</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Ren Wang" sort="Peng, Ren Wang" uniqKey="Peng R" first="Ren-Wang" last="Peng">Ren-Wang Peng</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of General Thoracic Surgery, Department of BioMedical Research, Inselspital, Bern University Hospital, University of Bern</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Oncology</title><idno type="eISSN">2234-943X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In non-small cell lung cancer (NSCLC), the most frequent oncogenic mutation in western countries is <italic>KRAS</italic>, for which, however, there remains no clinically approved targeted therapies. Recent progress on high biological heterogeneity including diverse <italic>KRAS</italic> point mutations, varying dependence on mutant <italic>KRAS</italic>, wide spectrum of other co-occurring genetic alterations, as well as distinct cellular status across the epithelial-to-mesenchymal transition (EMT), has not only deepened our understanding about the pathobiology of <italic>KRAS</italic>-mutant NSCLC but also brought about unprecedented new hopes for precision treatment of patients. In this review, we provide an update on the most recent advances in <italic>KRAS</italic>-mutant lung cancer, with a focus on mechanistic insights into tumor heterogeneity, the potential clinic implications and new therapies on horizons tailored for <italic>KRAS</italic>-mutant lung cancer.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dearden, S" uniqKey="Dearden S">S Dearden</name></author><author><name sortKey="Stevens, J" uniqKey="Stevens J">J Stevens</name></author><author><name sortKey="Wu, Yl" uniqKey="Wu Y">YL Wu</name></author><author><name sortKey="Blowers, D" uniqKey="Blowers D">D 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Sharma</name></author><author><name sortKey="Sanmamed, Mf" uniqKey="Sanmamed M">MF Sanmamed</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Yang, Haitang" sort="Yang, Haitang" uniqKey="Yang H" first="Haitang" last="Yang">Haitang Yang</name></noRegion><name sortKey="Liang, Shun Qing" sort="Liang, Shun Qing" uniqKey="Liang S" first="Shun-Qing" last="Liang">Shun-Qing Liang</name><name sortKey="Peng, Ren Wang" sort="Peng, Ren Wang" uniqKey="Peng R" first="Ren-Wang" last="Peng">Ren-Wang Peng</name><name sortKey="Schmid, Ralph A" sort="Schmid, Ralph A" uniqKey="Schmid R" first="Ralph A." last="Schmid">Ralph A. Schmid</name></country><country name="États-Unis"><noRegion><name sortKey="Liang, Shun Qing" sort="Liang, Shun Qing" uniqKey="Liang S" first="Shun-Qing" last="Liang">Shun-Qing Liang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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